Hi Friend

If you have hypermobile Ehlers-Danlos syndrome (hEDS) and ADHD, you're not alone—and it's not a coincidence. Research is increasingly showing that these two conditions overlap far more often than chance would predict, suggesting they may share underlying biological mechanisms.

Studies have found that people with hEDS are significantly more likely to have ADHD compared to the general population. One study found ADHD rates as high as 40-50% in people with hypermobility spectrum disorders and hEDS, compared to about 5-8% in the general population.

While researchers are still working to understand the full picture, several theories are emerging:

Connective Tissue and the Brain
Collagen and connective tissue don't just hold our bodies together—they're also present throughout the brain and nervous system. Differences in connective tissue structure may affect neurotransmitter function, particularly dopamine, which plays a key role in ADHD.

Autonomic Nervous System Dysfunction
Many people with hEDS experience dysautonomia (problems with the autonomic nervous system). This same system affects attention, impulse control, and executive function—core features of ADHD.

Inflammation and Mast Cell Activation
Both conditions have been linked to increased inflammation and mast cell issues, which can impact brain function and neurotransmitter balance.

Shared Genetic Factors
While the specific genes haven't been fully identified, there's growing evidence that hEDS and ADHD may share genetic underpinnings, possibly related to genes involved in connective tissue formation and neurological development.

Diagnosis Matters
If you have hEDS but struggle with focus, organisation, time management, or emotional regulation, it's worth discussing ADHD screening with a understanding doctor. Conversely, if you have ADHD and experience joint hypermobility, chronic pain, or frequent injuries, consider diagnosis for hEDS. if you have ongoing widespread symptoms MCAS also needs to be considered.

Treatment Considerations
Some ADHD medications (particularly stimulants) can affect heart rate and blood pressure, which is important if you also have dysautonomia or POTS. Work with doctors familiar with both conditions to find the right approach. Ideally a team that has a holistic doctor working with a psychiatrist in the team, so conversations around the best medication regime can be had, this is key!

Executive Function and Pain Management
ADHD can make it harder to maintain complex treatment regimens, remember physical therapy exercises, or track symptoms—all crucial for managing hEDS. Recognising this overlap can help you develop more realistic and compassionate self-management strategies.

You're Not "Just Lazy" or "Not Trying Hard Enough"
The combination of chronic pain, fatigue, and ADHD creates real neurological and physical barriers. Understanding that these conditions are interconnected can help combat internalised shame and self-blame.

Research into the hEDS-ADHD connection is still emerging, but the growing recognition of this overlap is validating for many who've felt dismissed or misunderstood. You're not imagining the connection—your experience reflects real biological relationships that science is only beginning to understand.

If you're navigating both conditions, remember: you're managing two complex, interconnected conditions. Be kind to yourself, seek doctors who understand both.

The Mend clinic is now fully booked, there are some exciting times ahead, we will have a consultant psychiatrist joining the team soon, to ensure there is really good care for people with complex chronic illnesses and overlapping AuDHD. The Patient dashboard os also live to enable constant communication with your care team when you need it.

Please click here to join the cancellation list or be informed when new slots open/updates.

Stay Well

Dr Ahmed