Hi Friend,
If you are living with Fibromyalgia, ME/CFS, or MCAS, you know that the search for relief often feels like navigating a maze without a map.
We know that standard treatments don’t always touch the deep fatigue, the widespread pain, or the reactive immune system that defines these conditions. That is why today, we want to talk about a treatment that has been changing the conversation in chronic complex illness: Low Dose Naltrexone (LDN).
I can help see if you are suitable HERE
What is LDN?
Naltrexone was originally approved in the 1980s at high doses (50mg+) to treat opioid addiction. However, researchers eventually discovered that when taken at very low doses (usually between 0.5mg and 4.5mg), the drug behaves completely differently.
Instead of just blocking receptors, it acts as a glial cell modulator. In plain English? It calms down the cells in your nervous system that cause inflammation.
Why is this relevant for you?
For our patients at Mend Clinic, LDN is often a cornerstone therapy because it targets the underlying mechanism of all three conditions: Neuroinflammation.
1. For Fibromyalgia:
LDN helps regulate your body’s production of endorphins (your natural painkillers). Many patients report a reduction in pain severity and an increased pain threshold.
2. For ME/CFS:
By reducing inflammation in the brain (calming those microglial cells), LDN can help lift the heavy "brain fog" and assist with energy management. It isn't a cure for PEM (Post-Exertional Malaise), but it can help widen your "energy envelope."
3. For MCAS:
LDN helps modulate the immune system. For a system that is constantly over-reacting to triggers, LDN acts as a regulator, potentially lowering the frequency and severity of allergic-type reactions.
The Side Effects & Risks
We believe in transparency. While LDN is generally well-tolerated, especially compared to standard painkillers or steroids, it is not without potential side effects.
Vivid Dreams: This is the most common side effect. Because LDN boosts endorphins, it can lead to very colorful or lucid dreams during the first few weeks.
Sleep Disturbances: Some patients experience insomnia if they take it at night. This is often solved by switching to a morning dose.
Initial symptoms: Mild headaches or nausea can occur as your body adjusts.
Important Note: Because Naltrexone blocks opioid receptors, you cannot take LDN if you are currently taking opioid-based painkillers.
The "Low and Slow" Approach
If you have MCAS, we know your body is sensitive. At Mend Clinic, we don’t believe in a "one size fits all" dose. We titrate widely, often starting at extremely low micro-doses to ensure your system tolerates it well before working our way up.
Is LDN right for you?
LDN is not a magic bullet, but for many of our community members, it is the tool that turns the volume down on their symptoms, allowing them to engage with life again.
If you are interested in exploring whether Low Dose Naltrexone fits into your treatment plan, we are here to guide you safely.
Stay Well
